Scientists at the University of Leipzig have discovered an effective method for strengthening human bones. The secret lies in a specific receptor that has received little scientific attention until now. It may hold the key to treating osteoporosis and preventing age-related bone diseases.
GPR133
Researchers have discovered that the GPR133 receptor plays a central role in the formation and maintenance of bone strength. When this receptor is disrupted, mice develop symptoms similar to human osteoporosis. To test the possibility of reversible effects, the authors of the project used a new compound called AP503.
This receptor stimulator significantly improved bone strength in both healthy and osteoporotic mice. Its mechanism of action is based on a natural process. In bone tissue, GPR133 is activated by cellular interactions and mechanical loading, triggering the activity of osteoblasts. These cells build bone tissue and inhibit osteoclasts, which break it down.
The drug AP503 mimics this process, making bones stronger and more resilient. It could be used to prevent or restore bone density loss.
